Brain Nutrition : The Essential Guide to Feeding Your Mind

Knowledge Centre Brain Nutrition: The Essential Guide to Feeding Your Mind

Brain nutrition — the essential guide to feeding your mind

Your brain is, by any measure, one of the hungriest organs in your body. It accounts for roughly 2% of body weight yet consumes approximately 20% of your daily energy intake — a disproportionate appetite that makes brain nutrition one of the most consequential areas of health science.1

That metabolic hunger means your brain is acutely sensitive to what you eat. Decades of research across neuroscience, nutritional psychiatry, and cognitive psychology now point to a clear conclusion: the nutrients you consume directly affect how well you think, remember, and regulate your mood — both today and as you age. And the connections between food and brain function are more specific, and more fascinating, than most people realise.

Key Takeaways

  • Your brain uses roughly 20% of your total energy intake despite representing only 2% of body weight, making nutrition a critical factor in cognitive performance.1
  • Omega-3 fatty acids (particularly DHA), B vitamins, magnesium, choline, and polyphenols each support distinct aspects of brain function through well-studied biological mechanisms.
  • B vitamins and omega-3s work synergistically — the VITACOG trial found that B vitamin supplementation slowed brain atrophy only in participants with adequate omega-3 status.2
  • The MIND diet, which combines elements of the Mediterranean and DASH diets, was associated with cognitive function equivalent to being 7.5 years younger in the highest-adherence group.3
  • No single nutrient works in isolation; a whole-diet approach that includes diverse nutrient-dense foods provides the strongest evidence for long-term cognitive protection.
  • Iron, zinc, and vitamin D are frequently overlooked brain nutrients whose deficiency can impair cognition independently of other dietary factors.

Why Does Your Brain Need Specific Nutrients?

Your brain requires a constant supply of specific nutrients to maintain its structure, produce neurotransmitters, generate energy, and protect itself from oxidative damage. Unlike most organs, the brain cannot store significant energy reserves and depends on a continuous supply of glucose and micronutrients delivered through the bloodstream.1

What's interesting is how neatly brain nutrients fall into distinct functional categories, each serving a different role. Structural nutrients like omega-3 fatty acids form the physical architecture of neuronal membranes. Cofactor nutrients like B vitamins and magnesium enable the enzymatic reactions that produce neurotransmitters such as serotonin, dopamine, and acetylcholine.4 Protective nutrients like polyphenols and antioxidants defend neurons against the oxidative stress generated by the brain’s high metabolic rate. Energy-regulating nutrients like iron ensure adequate oxygen delivery to neural tissue.

These categories overlap significantly — and that overlap is itself revealing. Magnesium, for example, serves as both a cofactor in over 300 enzymatic reactions and as a regulator of the NMDA receptor, which is central to learning and memory.5 Understanding these interconnected roles explains why isolated nutrient supplementation often produces weaker results than whole-diet approaches — the brain needs the full orchestra, not just a single instrument.

Section Summary: The brain’s exceptional metabolic demands mean it relies on a continuous supply of structural, cofactor, protective, and energy-regulating nutrients. These categories overlap extensively, which is why dietary patterns outperform isolated nutrients in most research.

What Role Do Omega-3 Fatty Acids Play in Brain Health?

If there's one nutrient that shows up again and again in brain health research, it's DHA — a type of omega-3 fatty acid that constitutes approximately 10–20% of the total lipids in the brain. DHA is especially concentrated in gray matter, where it supports synaptic membrane fluidity, signal transduction, and neuroinflammation regulation.6

Here's something that catches many people off guard: the brain cannot efficiently synthesise DHA from its precursor alpha-linolenic acid (ALA). Conversion rates from ALA to DHA are estimated at below 1% in adults, which means dietary intake of preformed DHA — primarily from oily fish such as salmon, mackerel, sardines, and herring — is the most reliable way to maintain brain DHA levels.7 Eicosapentaenoic acid (EPA), the other major marine omega-3, plays a complementary anti-inflammatory role and has been associated with mood regulation in several meta-analyses.8

A 2025 systematic review and dose-response meta-analysis in Scientific Reports examined the effects of omega-3 supplementation on cognitive function across 58 randomised controlled trials. The analysis found that supplementation at approximately 2,000 mg per day was associated with significant improvements in attention, perceptual speed, language, and primary memory, with effects varying across cognitive domains and populations. The certainty of evidence varied by domain — moderate for perceptual speed, lower for attention — meaning replication in larger trials would strengthen these conclusions.9 This nuance matters: omega-3s appear most beneficial for specific cognitive domains and in populations with existing deficiency or mild cognitive impairment, rather than as a universal cognitive enhancer.

Plant-based sources of omega-3 (walnuts, flaxseed, chia seeds) provide ALA, which offers some cardiovascular benefits but does not reliably increase brain DHA. If you don’t eat fish, algae-derived DHA supplements offer a direct plant-based source of preformed DHA.

Section Summary: DHA is a critical structural component of brain cell membranes, but the body converts plant-based ALA to DHA very inefficiently. Oily fish and algae-based supplements are the most reliable sources. Evidence is strongest for attention and processing speed improvements, particularly in those with low baseline levels.

How Do B Vitamins Support Cognitive Function?

B vitamins — particularly folate (B9), vitamin B12, and vitamin B6 — support cognitive function primarily through their role in one-carbon metabolism, a biochemical pathway that regulates homocysteine levels, DNA methylation, and neurotransmitter synthesis.4

Elevated homocysteine is an established risk factor for brain atrophy and cognitive decline — and this is where the research gets particularly compelling. The landmark VITACOG trial — a 2010 randomised controlled trial involving 271 participants with mild cognitive impairment (168 of whom completed MRI analysis) — found that high-dose B vitamin supplementation (folic acid 0.8 mg, vitamin B12 0.5 mg, vitamin B6 20 mg) reduced the rate of whole-brain atrophy by 30% overall and by 53% in the MRI subgroup with homocysteine levels above 13 µmol/L.2

But here's the finding that really stands out. Further analysis from VITACOG revealed that the protective effects of B vitamins on brain atrophy occurred primarily in participants with adequate omega-3 fatty acid status — those with low omega-3 levels showed no significant benefit from B vitamins alone.10 The takeaway is broader than just B vitamins: nutrients rarely work in isolation, and understanding these partnerships changes how you think about brain nutrition.

Beyond homocysteine regulation, B vitamins serve as cofactors for the synthesis of serotonin (from tryptophan, requiring B6), dopamine, and noradrenaline. Folate also supports the production of brain-derived neurotrophic factor (BDNF), a protein essential for neuronal growth and synaptic plasticity.4

Rich dietary sources include leafy green vegetables (folate), animal products such as meat, fish, eggs, and dairy (B12), and whole grains, legumes, and poultry (B6). If you’re over 60 or follow a plant-based diet, vitamin B12 deserves particular attention — deficiency is common in these groups, making it one of the most important nutrients to monitor for long-term brain health.11

Section Summary: B vitamins regulate homocysteine, a known risk factor for brain atrophy, and serve as cofactors for neurotransmitter production. The VITACOG trial showed that B vitamins slowed brain shrinkage by up to 53% — but only when omega-3 status was adequate, highlighting the importance of nutrient synergy.

Why Is Magnesium Critical for Brain Function?

Magnesium is involved in over 300 enzymatic reactions in the body, but its most fascinating neurological role may be the one that's least well known. It acts as a natural voltage-dependent blocker of the N-methyl-D-aspartate (NMDA) receptor, a glutamate receptor that plays a central role in synaptic plasticity, learning, and memory formation.5

The mechanism is elegant: under normal conditions, magnesium ions sit within the NMDA receptor channel, preventing excessive calcium influx. When a neuron receives a sufficiently strong signal, magnesium is displaced, allowing calcium to enter and trigger the molecular cascades underlying learning and memory. Without adequate magnesium, this gating mechanism fails — resulting in excessive neuronal excitation (excitotoxicity) that can damage or kill neurons.5

A 2024 systematic review and meta-analysis published in Advances in Nutrition examined the relationship between magnesium and cognitive health across 3 RCTs and 12 cohort studies. The cohort evidence revealed something interesting: consistent U-shaped associations between serum magnesium and cognitive disorders, suggesting an optimal serum magnesium concentration of approximately 0.85 mmol/L — meaning both too little and too much may be problematic.12

Magnesium also supports brain health through additional mechanisms: maintaining blood-brain barrier integrity, supporting myelin sheath formation, and reducing neuroinflammation.5 Despite its importance, suboptimal magnesium status is surprisingly common — dietary surveys indicate that a substantial proportion of adults in developed countries consume less than the estimated average requirement, with older adults particularly affected.13

Your best dietary sources of magnesium include dark leafy greens (spinach, Swiss chard), nuts and seeds (pumpkin seeds, almonds), legumes, whole grains, and dark chocolate. The UK recommended nutrient intake is 300 mg per day for men and 270 mg per day for women.

Section Summary: Magnesium regulates the NMDA receptor, a molecular gatekeeper for learning and memory. Deficiency disrupts this gating mechanism and may accelerate cognitive decline. Subclinical deficiency is surprisingly common, making magnesium-rich foods an important part of brain-supportive nutrition.

What Is Choline’s Role in Memory and Brain Health?

Choline is one of those nutrients that punches well above its public profile. It serves as the precursor to acetylcholine, the primary neurotransmitter involved in memory, attention, and muscle control. Your brain also uses choline to synthesise phosphatidylcholine, a major structural component of neuronal cell membranes.14

The evidence for choline's cognitive importance is building steadily. A 2011 analysis of 1,391 participants in the Framingham Offspring Cohort found that higher dietary choline intake was significantly associated with better verbal and visual memory performance.15 More recently, a 2024 prospective cohort study from the China Health and Nutrition Survey followed participants over 22 years and found that higher choline intake was associated with slower cognitive decline — and the protective effect remained significant after adjustment for other dietary and lifestyle factors.16

Despite its importance, most adults do not meet the adequate intake for choline (550 mg per day for men, 425 mg per day for women, based on US Institute of Medicine values). A 2017 review in Nutrients highlighted that dietary choline exerts neuroprotective effects throughout the lifespan, with particular relevance during early brain development, ageing, and in populations at risk of Alzheimer’s disease.14

Eggs are the single richest common dietary source of choline, with one large egg providing approximately 150 mg. Other good sources include liver, beef, fish, soya beans, and cruciferous vegetables such as broccoli and Brussels sprouts.

Section Summary: Choline is the building block for acetylcholine, the brain’s primary memory neurotransmitter, and for neuronal cell membrane structure. Most adults fall short of the adequate intake, making choline-rich foods — particularly eggs, liver, and soya — an often-overlooked priority for brain nutrition.

How Do Antioxidants and Polyphenols Protect the Brain?

The brain’s high metabolic rate generates substantial reactive oxygen species (ROS), making it particularly vulnerable to oxidative damage. This is where antioxidants and polyphenols come in — plant-derived compounds found abundantly in berries, green tea, dark chocolate, and colourful vegetables that help neutralise these free radicals and reduce neuroinflammation.17

Anthocyanins — the pigments responsible for the deep colour of blueberries, blackberries, and other dark-hued fruits — have received particular research attention, and for good reason. A 2025 systematic review of 14 randomised clinical trials found trends toward cognitive improvement with anthocyanin supplementation, though pooled effects did not reach statistical significance across individual cognitive domains.18 A larger 2025 meta-analysis of 59 RCTs reported that anthocyanin and anthocyanin-rich food interventions significantly improved global cognition (standardised mean difference = 0.46, 95% CI 0.30–0.63), with effects observed across multiple cognitive domains including attention, episodic memory, and working memory.30

One study that particularly caught our attention: a small double-blind randomised controlled trial (n=61) published in The American Journal of Clinical Nutrition (2023) studied healthy older adults aged 65–80 who received either 26 g of freeze-dried wild blueberry powder (providing 302 mg of anthocyanins) or a matched placebo daily. The blueberry group showed significant improvements in both vascular function and cognitive performance, suggesting that the cognitive benefits may be partly mediated through improved cerebral blood flow. Larger trials are needed to confirm these findings.19

Vitamin E (found in nuts, seeds, and vegetable oils) and vitamin C (found in citrus fruits, peppers, and kiwi) are classical antioxidants that also contribute to neuroprotection. Vitamin C additionally serves as a cofactor in the synthesis of noradrenaline and supports iron absorption — a nice example of how antioxidant and energy-regulating functions connect.17

Flavanols from dark chocolate and cocoa have been associated with improvements in cerebral blood flow and some aspects of working memory, though the evidence base is smaller than for berry anthocyanins.

Section Summary: The brain’s high oxygen consumption makes it especially vulnerable to oxidative damage. Berry anthocyanins show the strongest evidence among polyphenols, with the largest meta-analysis (59 RCTs) reporting significant cognitive improvements across multiple domains — particularly with consistent intake over 12 weeks or more.

Which Other Nutrients Does Your Brain Need?

Beyond the major nutrients above, several additional micronutrients play important but often overlooked roles in brain function. These deserve more attention than they typically get.

Iron

Iron is essential for oxygen transport to the brain via haemoglobin and myoglobin. It also serves as a cofactor for enzymes involved in neurotransmitter synthesis (dopamine, serotonin, noradrenaline) and myelin production. Iron deficiency — the world’s most common nutritional deficiency — impairs cognitive function through reduced cerebral oxygen delivery. A 2014 review in Neuropsychiatric Disease and Treatment concluded that iron deficiency — even in the absence of anaemia — is associated with measurable cognitive deficits across the lifespan, with the largest effects observed in infants, children, and women of reproductive age.20 Separate prospective studies have linked anaemia in older adults with increased dementia risk, though precise estimates vary across cohorts.

Zinc

Zinc is concentrated in the hippocampus, the brain region most involved in memory formation. It modulates synaptic transmission and plays a role in NMDA receptor function alongside magnesium. Zinc deficiency has been linked to impaired learning and memory in both animal and human studies.21 Good sources include shellfish, red meat, pumpkin seeds, and legumes.

Vitamin D

Vitamin D receptors are distributed throughout the brain, particularly in regions involved in memory and mood regulation. Observational studies have consistently associated low vitamin D status with increased risk of cognitive impairment and dementia, though randomised controlled trials have produced mixed results regarding supplementation benefits.22 Given the high prevalence of vitamin D insufficiency in the UK (particularly during winter months), maintaining adequate levels through sunlight exposure, fortified foods, or supplementation remains a reasonable strategy for brain health.

Section Summary: Iron, zinc, and vitamin D each play distinct roles in brain function — from oxygen transport to synaptic signalling to neuroprotection. Deficiency in any of these is common and can independently impair cognition.

How Do Key Brain Nutrients Compare?

Nutrient Primary Brain Function Top Food Sources Evidence Strength
Omega-3 (DHA) Membrane structure, anti-inflammatory signalling Salmon, mackerel, sardines, algae Strong (multiple RCTs and meta-analyses)
Folate (B9) Homocysteine regulation, BDNF production Leafy greens, legumes, fortified grains Strong (VITACOG RCT, cohort studies)
Vitamin B12 Myelin maintenance, homocysteine regulation Meat, fish, dairy, eggs Strong (deficiency well-characterised)
Magnesium NMDA receptor regulation, enzyme cofactor Dark leafy greens, nuts, seeds, legumes Moderate-strong (observational + some RCTs)
Choline Acetylcholine synthesis, membrane phospholipids Eggs, liver, soya, cruciferous vegetables Moderate (cohort studies, mechanistic evidence)
Anthocyanins Antioxidant protection, cerebral blood flow Blueberries, blackberries, cherries Moderate-strong (RCTs, two meta-analyses)
Iron Oxygen transport, neurotransmitter synthesis Red meat, legumes, dark leafy greens Strong (deficiency effects well-documented)
Zinc Hippocampal signalling, NMDA receptor modulation Shellfish, red meat, pumpkin seeds Moderate (animal + limited human data)
Vitamin D Neuroprotection, mood regulation Sunlight, oily fish, fortified foods Mixed (strong observational, mixed RCTs)

Which Dietary Patterns Best Support Brain Health?

Individual nutrients matter, but here's what the research consistently tells us: the strongest evidence for long-term cognitive protection comes from whole dietary patterns rather than isolated supplements. Three patterns have the most research support.

The Mediterranean Diet

The Mediterranean diet — characterised by high consumption of vegetables, fruits, legumes, whole grains, olive oil, and fish, with moderate dairy and low red meat — has been associated with reduced risk of cognitive impairment across multiple large-scale studies. A 2025 meta-analysis in GeroScience synthesising data from studies published between 2000 and 2024 confirmed that higher Mediterranean diet adherence was associated with significantly reduced risk of cognitive impairment, dementia, and Alzheimer’s disease.23

The MIND Diet

The MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) was specifically designed to target brain health by combining elements of the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets. It emphasises ten brain-healthy food groups — green leafy vegetables, other vegetables, nuts, berries, beans, whole grains, fish, poultry, olive oil, and wine in moderation — while limiting five food groups associated with cognitive harm (red meat, butter and margarine, cheese, pastries and sweets, and fried or fast food).3

The original 2015 observational study produced a striking finding. It followed 960 participants from the Rush Memory and Aging Project over an average of 4.7 years and found that those in the highest tertile of MIND diet adherence had a rate of cognitive decline equivalent to being 7.5 years younger than the lowest-adherence group. The association held across all five cognitive domains measured: episodic memory, working memory, semantic memory, visuospatial ability, and perceptual speed.3

However — and this is worth being honest about — a 2023 randomised controlled trial published in The New England Journal of Medicine (the MIND Trial) found that the MIND diet did not significantly slow cognitive decline compared with a control diet with mild caloric restriction over 3 years in cognitively unimpaired adults.24 This discrepancy between observational and interventional findings is common in nutritional research and likely reflects the difficulty of maintaining dietary adherence in trial settings, the relatively short intervention period, and the possibility that lifelong dietary patterns matter more than short-term changes.

The Nordic Diet

The Nordic diet — emphasising berries, root vegetables, fatty fish, whole grains, rapeseed oil, and foraged foods — shares many brain-supportive characteristics with the Mediterranean pattern but uses locally available Northern European ingredients. A Swedish cohort study (n=2,223, 6-year follow-up) found that adherence to a prudent dietary pattern emphasising vegetables, fruit, fish, and oils — many of which overlap with the Nordic dietary tradition — may help attenuate the cognitive effects of a Western diet.25 Direct evidence specifically evaluating the Nordic diet remains more limited than for the Mediterranean or MIND patterns.

Dietary Pattern Key Brain-Healthy Components Evidence for Cognitive Benefits Best Suited For
Mediterranean Olive oil, fish, vegetables, legumes Strong (multiple meta-analyses) Long-term neuroprotection
MIND Leafy greens, berries, nuts, fish Strong observational; mixed RCT Targeted brain health focus
Nordic Berries, fatty fish, root vegetables, rapeseed oil Emerging (fewer large studies) Northern European food preferences
Section Summary: Whole dietary patterns provide stronger cognitive protection than individual nutrients. The Mediterranean and MIND diets have the most evidence, though a recent RCT produced less clear-cut results for the MIND diet — a common pattern in nutritional research where lifelong habits may matter more than short-term interventions.

How Do Nutrients Interact to Support Your Brain?

One of the most important — and most underappreciated — principles in brain nutrition is that nutrients work together, not in isolation. And some of these partnerships are genuinely surprising.

B vitamins and omega-3 fatty acids: As the VITACOG trial demonstrated, B vitamins slowed brain atrophy effectively only when participants had adequate omega-3 status.10 The proposed mechanism involves B vitamins facilitating the formation of phosphatidylcholine enriched with omega-3 fatty acids, enhancing DHA transport into the brain.

Vitamin C and iron: Vitamin C significantly improves the absorption of non-haem iron (the form found in plant foods), making it particularly important for vegetarians and vegans who rely on plant-based iron sources to support brain oxygenation.26

Magnesium and vitamin D: Here's a connection that often gets missed: magnesium is required for the activation of vitamin D — the enzymes that convert vitamin D to its active form are magnesium-dependent. Low magnesium status can therefore contribute to functional vitamin D deficiency even when vitamin D intake appears adequate.27

Polyphenols and gut microbiome: Emerging research on the gut-brain axis suggests that many polyphenols exert their cognitive benefits partly through modulation of gut bacteria, which produce neuroactive metabolites including short-chain fatty acids and precursors to neurotransmitters.28

These interactions explain why whole-food dietary patterns consistently outperform single-nutrient supplementation in long-term studies. And the practical takeaway is actually encouraging: a varied diet rich in vegetables, fruit, oily fish, nuts, seeds, legumes, and whole grains naturally provides these nutrients in the combinations and ratios that enable synergistic effects — meaning real-world brain nutrition is often simpler than the science might suggest.

Section Summary: Nutrients interact in ways that amplify their individual effects — B vitamins need omega-3s, iron needs vitamin C, and vitamin D needs magnesium. This is why dietary pattern research consistently shows stronger cognitive benefits than single-nutrient supplementation studies.

Frequently Asked Questions

What is the single best food for brain health?

No single food can optimise brain health on its own. However, oily fish (salmon, mackerel, sardines) consistently ranks among the most evidence-supported brain foods because it provides preformed DHA, high-quality protein, vitamin D, and selenium in a single source. Aim for at least two portions of oily fish per week, as recommended by the NHS.7

Can supplements replace a brain-healthy diet?

Supplements can address specific deficiencies — particularly vitamin B12, vitamin D, and omega-3 in groups at risk — but they cannot replicate the complex nutrient interactions, fibre, and phytochemical diversity of whole foods. Current evidence supports a food-first approach, with targeted supplementation where your dietary intake is insufficient.11

How quickly can dietary changes affect brain function?

Some effects are relatively rapid: improved cerebral blood flow from flavonoid-rich foods has been measured within hours of consumption. However, the structural and protective benefits of brain-supportive nutrition — such as reduced brain atrophy and lower dementia risk — develop over months to years of consistent dietary patterns.19

Is the MIND diet better than the Mediterranean diet for brain health?

Both diets share many core elements and both have strong observational evidence for cognitive benefits. The MIND diet was specifically designed for brain health and is more prescriptive about berries and leafy greens, while the Mediterranean diet has a broader evidence base across multiple health outcomes. In practice, either pattern — or a combination — supports brain health effectively.3

Does sugar damage the brain?

Chronic high sugar intake has been associated with impaired memory and lower cognitive test scores in observational studies. Diets high in ultra-processed foods and added sugars are consistently associated with worse cognitive outcomes compared with whole-food dietary patterns.29

Which nutrients are most important for brain health after 50?

Vitamin B12, omega-3 DHA, vitamin D, and magnesium become particularly important with age. B12 absorption declines with age due to reduced stomach acid production; DHA supports ongoing membrane maintenance; vitamin D levels often drop due to reduced sun exposure and skin synthesis capacity; and magnesium intake frequently falls below recommended levels in older adults.11

Are there risks to taking brain health supplements?

Most brain-supportive nutrients are safe at dietary and standard supplemental doses. However, iron supplementation should only be undertaken when deficiency is confirmed by blood testing, as excess iron can be neurotoxic. High-dose omega-3 supplementation (typically above 3 g per day) has historically been flagged for bleeding risk in individuals on anticoagulant medications, although recent systematic reviews suggest clinically significant bleeding events are rare. Discuss with your healthcare provider before combining higher-dose omega-3s with blood-thinning drugs. High-dose single-nutrient supplements can also interfere with the absorption of other nutrients — another reason to prioritise a food-first approach.20

This article is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement regimen, especially if you are taking medication.

Supporting Your Brain Nutrition

Maintaining optimal brain nutrition involves ensuring adequate intake of the key nutrients discussed in this guide — from omega-3 fatty acids and B vitamins to magnesium and choline. A nutrient-dense diet forms the foundation, and targeted supplementation can help fill specific gaps.

When choosing a brain health supplement, look for formulations that deliver these nutrients at evidence-supported doses — particularly omega-3 DHA, B vitamins (including folate and B12), magnesium, and choline. BrainSmart's Ultra formulation combines many of the key nutrients discussed in this guide. You can explore the full range here.

Related Reading

Explore more evidence-based brain health guides from our Knowledge Centre.

References

  1. Raichle ME, Gusnard DA. Appraising the brain’s energy budget. Proc Natl Acad Sci U S A. 2002;99(16):10237-10239. doi:10.1073/pnas.172399499
  2. Smith AD, Smith SM, de Jager CA, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010;5(9):e12244. doi:10.1371/journal.pone.0012244
  3. Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11(9):1015-1022. doi:10.1016/j.jalz.2015.04.011
  4. Kennedy DO. B vitamins and the brain: mechanisms, dose and efficacy — a review. Nutrients. 2016;8(2):68. doi:10.3390/nu8020068
  5. Kirkland AE, Sarlo GL, Holton KF. The role of magnesium in neurological disorders. Nutrients. 2018;10(6):730. doi:10.3390/nu10060730
  6. Weiser MJ, Butt CM, Mohajeri MH. Docosahexaenoic acid and cognition throughout the lifespan. Nutrients. 2016;8(2):99. doi:10.3390/nu8020099
  7. Burdge GC, Calder PC. Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev. 2005;45(5):581-597. doi:10.1051/rnd:2005047
  8. Liao Y, Xie B, Zhang H, et al. Efficacy of omega-3 PUFAs in depression: a meta-analysis. Transl Psychiatry. 2019;9(1):190. doi:10.1038/s41398-019-0515-5
  9. Shahinfar H, Yazdian Z, Asgari Avini N, et al. A systematic review and dose response meta-analysis of omega-3 supplementation on cognitive function. Sci Rep. 2025;15:30610. doi:10.1038/s41598-025-16129-8
  10. Jerneren F, Elshorbagy AK, Oulhaj A, et al. Brain atrophy in cognitively impaired elderly: the importance of long-chain omega-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015;102(1):215-221. doi:10.3945/ajcn.114.103283
  11. Moore K, Hughes CF, Ward M, et al. Diet, nutrition and the ageing brain: current evidence and new directions. Proc Nutr Soc. 2018;77(2):152-163. doi:10.1017/S0029665117004177
  12. Chen F, Wang J, Cheng Y, et al. Magnesium and cognitive health in adults: a systematic review and meta-analysis. Adv Nutr. 2024;15(8):100272. doi:10.1016/j.advnut.2024.100272
  13. Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev. 2012;70(3):153-164. doi:10.1111/j.1753-4887.2011.00465.x
  14. Blusztajn JK, Slack BE, Mellott TJ. Neuroprotective actions of dietary choline. Nutrients. 2017;9(8):815. doi:10.3390/nu9080815
  15. Poly C, Massaro JM, Seshadri S, et al. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr. 2011;94(6):1584-1591. doi:10.3945/ajcn.110.008938
  16. Huang F, Guan F, Jia X, et al. Dietary choline intake is beneficial for cognitive function and delays cognitive decline: a 22-year large-scale prospective cohort study. Nutrients. 2024;16(17):2845. doi:10.3390/nu16172845
  17. Gomez-Pinilla F, Nguyen TTJ. Natural mood foods: the actions of polyphenols against psychiatric and cognitive disorders. Nutr Neurosci. 2012;15(3):127-133. doi:10.1179/1476830511Y.0000000035
  18. Lorzadeh E, Weston-Green K, Roodenrys S, et al. The effect of anthocyanins on cognition: a systematic review and meta-analysis of randomized clinical trial studies in cognitively impaired and healthy adults. Curr Nutr Rep. 2025;14(1):14. doi:10.1007/s13668-024-00595-z
  19. Wood E, Hein S, Mesnage R, et al. Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial. Am J Clin Nutr. 2023;117(6):1306-1319. doi:10.1016/j.ajcnut.2023.03.017
  20. Jáuregui-Lobera I. Iron deficiency and cognitive functions. Neuropsychiatr Dis Treat. 2014;10:2087-2095. doi:10.2147/NDT.S72491
  21. Takeda A. Zinc homeostasis and functions of zinc in the brain. Biometals. 2001;14(3-4):343-351. doi:10.1023/A:1012982123386
  22. Annweiler C, Llewellyn DJ, Beauchet O. Low serum vitamin D concentrations in Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis. 2013;33(3):659-674. doi:10.3233/JAD-2012-121432
  23. Fekete M, Varga P, Ungvari Z, et al. The role of the Mediterranean diet in reducing the risk of cognitive impairment, dementia, and Alzheimer’s disease: a meta-analysis. GeroScience. 2025;47:3111-3130. doi:10.1007/s11357-024-01488-3
  24. Barnes LL, Dhana K, Liu X, et al. Trial of the MIND diet for prevention of cognitive decline in older persons. N Engl J Med. 2023;389(7):602-611. doi:10.1056/NEJMoa2302368
  25. Shakersain B, Santoni G, Larsson SC, et al. Prudent diet may attenuate the adverse effects of Western diet on cognitive decline. Alzheimers Dement. 2016;12(2):100-109. doi:10.1016/j.jalz.2015.08.002
  26. Hallberg L, Brune M, Rossander L. Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate. Am J Clin Nutr. 1989;49(1):140-144. doi:10.1093/ajcn/49.1.140
  27. Uwitonze AM, Razzaque MS. Role of magnesium in vitamin D activation and function. J Am Osteopath Assoc. 2018;118(3):181-189. doi:10.7556/jaoa.2018.037
  28. Cryan JF, O’Riordan KJ, Cowan CSM, et al. The microbiota-gut-brain axis. Physiol Rev. 2019;99(4):1877-2013. doi:10.1152/physrev.00018.2018
  29. Ye X, Gao X, Scott T, et al. Habitual sugar intake and cognitive function among middle-aged and older Puerto Ricans without diabetes. Br J Nutr. 2011;106(9):1423-1432. doi:10.1017/S0007114511001760
  30. Micek A, Godos J, Giampieri F, et al. The effect of anthocyanins and anthocyanin-rich foods on cognitive function: a meta-analysis of randomized controlled trials. GeroScience. 2025. doi:10.1007/s11357-025-02008-7
Tom Kaplan, Brain Health Writer at BrainSmart

Tom Kaplan

Brain Health Writer at BrainSmart

Tom Kaplan is a specialist health writer focused on cognitive health, brain nutrition, and evidence-based approaches to supporting mental performance across the lifespan. His work draws on peer-reviewed research across neuroscience, nutritional psychiatry, and cognitive psychology — translating complex clinical findings into clear, practical guidance that helps readers make informed decisions about their brain health. Read full bio →

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